Nerve growth factor (NGF) induces neuronal differentiation in neuroblastoma cells transfected with the NGF receptor cDNA.
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منابع مشابه
The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.
Protein tyrosine phosphorylation is a potential mechanism for initial signaling in PC12 cells during differentiation in response to nerve growth factor (NGF). NGF-induced tyrosine phosphorylation has been found to be initiated by the trk protooncogene, which participates in the formation of high-affinity NGF binding sites. In contrast to transfection of wild-type low-affinity p75 NGF receptors,...
متن کاملSpecific Binding of Nerve Growth Factor (ngf) by Murine C 1300 Neuroblastoma Cells
Murine C 1300 neuroblastoma cells bind with high avidity on their membrane surface the nerve growth factor (NGF), a protein capable of inducing differentiation of sympathetic nerve cells. The total binding capacity of NGF by the cells was quantitatively measured by a radioimmunoassay technique, using (125)I-labeled NGF. An average number of about 10(6) molecules of NGF could be bound, at satura...
متن کاملCell-Type-specific Regulation of Nerve Growth Factor (NGF) Synthesis in Non-neuronal Cells
We have previously show" thai after peripheral nerve lesion the synthesis 0' NGF is induced in cells 01 the nerve sheath (Heumann el 81., 19878). Further analysis led 10 the identiflcation 01 growth factars and intracellular mechanisms responsible 10r this induction in sciatic fibroblasts (lind holm el 81., 1988; Hengerer el 81., 1990). The prese"t work aimed al the elucidation of the regulatio...
متن کاملImmunology of nerve growth factor (NGF). The effect of NGF-antiserum on sensory ganglia in vitro.
The properties of the 'Nerve Growth Factor' (NGF) have been described extensively (Levi-Montalcini & Booker, 1960; Levi-Montalcini, 1965) and reviewed recently (Levi-Montalcini, 1966). This factor is a protein of molecular weight about 130000 in its aggregated form (Varon, Nomura & Shooter, 1967, 1968) but may be active in lower molecular weight forms (Cohen, 1959, 1960; Banks et al. 1968). It ...
متن کاملImmunology of nerve growth factor (NGF). The effect of NGF-antiserum on sensory ganglia in vitro
The properties of the 'Nerve Growth Factor' (NGF) have been described extensively (Levi-Montalcini & Booker, 1960; Levi-Montalcini, 1965) and reviewed recently (Levi-Montalcini, 1966). This factor is a protein of molecular weight about 130000 in its aggregated form (Varon, Nomura & Shooter, 1967, 1968) but may be active in lower molecular weight forms (Cohen, 1959, 1960; Banks et al. 1968). It ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1990
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.10.9.5015